Paroxetine is a potent and selective inhibitor of the capture of 5-hydroxytryptamine (5-HT, serotonin) by brain neurons, which determines its antidepressant effect and effectiveness in the treatment of obsessive-compulsive (OCD) and panic disorder.
The major metabolites of paroxetine are polar and conjugated oxidation and methylation products, which are rapidly excreted from the body, have weak pharmacological activity and do not affect its therapeutic effect. Paroxetine does not violate the psychomotor functions and does not potentiate the inhibitory effect of ethanol on them.
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