The drug contains a man-made hormone-glucocorticosteroid, with a pronounced anti-inflammatory, anti-shock, immunosuppressive (cuts down on the activity of cells from the defense mechanisms), antiallergic and antitoxic action.
It energizes the formation of proteins that hinder the enzyme phospholipase A2, inhibits the discharge of arachidonic acidity and producing substances responsible to add mass to inflammation and allergic reactions (prostaglandins, endoperoxides, leukotrienes). Dexamethasone affects protein metabolic process, reducing the amount of globulins with growing albumin / globulin ratio, as well as boosts the albumin production within the kidneys, liver, and improves the destruction of protein within the muscles. The drug impacts fat metabolic process: zinc heightens producing greater essential fatty acids, triglycerides, redistributes fat (plays a role in the buildup of fat hard, abdomen, shoulder girdle), results in hypercholesterolemia (elevated levels of cholesterol). Impacts the metabolic process of carbohydrates: boosts the absorption of carbohydrates, promotes the discharge of glucose in the liver in to the bloodstream, the activation of gluconeogenesis (the development of glucose). Dexamethasone comes with an hostile impact on vitamin D, creating a “washing out” of calcium in the bones, growing its excretion through the kidneys.
Directions for use
Dosage varies based on what’s prescribed this drug. At the outset of therapy as well as in a severe period, greater doses are utilized, once the expected effect is achieved, the dosage is reduced. The time period of the program is dependent upon the physician individually for every patient.
The start of treatment and severe cases suggest using 10-15 mg of medicine each day, maintaining a regular dose of just 2-5 mg. When treating asthmatic status and acute allergic reactions, it’s suggested to consider 2-3 mg from the drug each day. If it’s essential to eliminate adrenogenital syndrome, the physician selects a serving of Dexamethasone with respect to the excretion of 17-ketosteroids within the urine. Usually, in cases like this, 1-1.5 mg from the drug each day is enough.
When the average daily dose comes from two to three mg, then your reception is split into 2-3 occasions. When treating in small doses, it’s suggested to accept drug each morning.
With prolonged (greater than 2 days) treatment, you’ll be able to develop functional insufficiency from the adrenal cortex, sometimes weight problems, muscle weakness, elevated bloodstream pressure, brittle bones, hyperglycemia (decreased glucose tolerance), diabetes, impaired secretion of sex hormones (amenorrhoea, hirsutism, impotence) , moonlike face, the look of striae, petechiae, ecchymosis, steroid acne sodium retention can happen using the formation of edema, elevated discharge of potassium, atrophy from the adrenal cortex, vasculitis (including like a symbol of withdrawal syndrome with prolonged therapy), epigastric discomfort, peptic ulcer from the stomach, immunosuppression, elevated chance of infection, thrombosis delayed healing of wounds, stunted development in children, glaucoma, cataracts, mental disorders, pancreatitis.
For lengthy-term utilization, aside from emergency and substitution therapy, contraindications are peptic ulcer from the stomach or duodenum, severe types of brittle bones, mental illness within the anamnesis, shingles, rosacea, chickenpox, the time of 8 days before and a pair of days after vaccination, lymphadenitis after prophylactic vaccination against tuberculosis, amoebic infection, systemic mycoses, poliomyelitis, closed-position and open-position glaucoma.
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